Endocrine Abstracts

Introduction: Predictors for therapeutical response of SGLT-2 inhibitors (SGLT2i) is scarcely studied. The aim of the study was to retrospectively analyse the clinical parameters that contribute to the therapeutic outcomes of SGLT2i.Methods/design: We enrolled 75 patients with type 2 diabetes mellitus (T2DM), treated with SGLT2i for longer than three months. The patients were divided into two groups: good responders (if HbA1c-lowering effects were &#8805...

Introduction: Association between liver fibrosis and body mass index (BMI) is well known in HIV/HCV patients, is linked to worse lipid profile and is widely used to predict liver fibrosis in this population. Nevertheless, recent studies show a stronger link between dyslipidemia and liver stiffness with visceral adiposity index (VAI) in general population. The main aim of this study was to investigate the accuracy of VAI and BMI as predictors for liver fibrosis and dyslipidemia...

With the wide-spread use of abiraterone/enzalutamide for CRPC, there is an urgent need to understand and reverse resistance to these treatments. Studies have implicated glucocorticoid receptor (GR) as activating androgen receptor (AR) signalling and driving resistance. Here we studied progesterone receptor (PR), which is phylogenetically most closely related to the AR. We first used digital droplet PCR in prostate cancer (PCa) cell lines and observed >10 times higher level...

Introduction: The prevalence of Transgender individuals seeking gender affirming hormone therapy (GAHT) has been increasing. This therapy has been known to be highly effective in the treatment of gender dysphoria and enhancing mental health in this population.Aim: To evaluate the overall impact of GAHT on self-esteem, well-being and social/familial relations in the Portuguese adult transgender populationMethods: Cross-sectional stu...

Respiratory muscle weakness and diaphragmatic failure is a rare presentation of hypercortisolism. We report a case of Cushing’s syndrome in a 60-year-old female with history of rheumatoid arthritis, biliary cirrhosis and hypothyroidism. She presented to the Respiratory Physicians with progressive worsening of shortness of breath. Clinical assessment excluded infective pathology, cardiac failure or asthma. Pulmonary function tests (PFT) showed re...

Respiratory muscle weakness and diaphragmatic failure is a rare presentation of hypercortisolism. We report a case of Cushing’s syndrome in a 60-year-old female with history of rheumatoid arthritis, biliary cirrhosis and hypothyroidism. She presented to the Respiratory Physicians with progressive worsening of shortness of breath. Clinical assessment excluded infective pathology, cardiac failure or asthma. Pulmonary function tests (PFT) showed re...

We have previously described how signaling responses for the glucagon-like peptide-1 receptor (GLP-1R), a class B GPCR that plays key roles in metabolic regulation and is a prime type 2 diabetes (T2D) target, are modulated by intracellular membrane trafficking. We have also recently shown that binding to the therapeutic GLP-1R agonist exendin-4 (Exenatide) triggers increased clustering and segregation of biologically active GLP-1Rs into cholesterol-rich plasma membrane nanodom...

Introduction: Megestrol acetate (MA) is commonly used to promote weight gain in patients with HIV infection. Adrenal insufficiency (AI) has been reported as an adverse effect of MA but this association is not frequently recognized in clinical practice and only few cases develop symptoms of AI. We describe a case of symptomatic AI precipitated by Graves’ hyperthyroidism in a HIV patient on long-term MA treatment.Case report: A 44-year-old man with HI...

Introduction: Children with TPS and/or ICDI represent a diagnostic and management conundrum. Agreed radiological criteria for TPS are lacking.Aims: To longitudinally characterize the neuroradiological features of children presenting with TPS and/or ICDI due to different aetiologies (oncological, inflammatory, idiopathic).Methods: We searched the terms ‘thickened pituitary stalk’ or ‘idiopathic diabetes insipidus&#146...

Introduction: Hypoglycemia is the most frequent metabolic complication observed in patients with type 2 diabetes mellitus (T2DM). Moreover, rare insulinomas are the most common cause of endogenous hyperinsulinemic hypoglycemia in adults. The coincidence of insulinoma in a patient with pre-existing T2DM is an extremely rare condition and there are few case reports in the medical literature.Case report: A 76-year-old woman diagnosed with T2DM 6 years ago, ...